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Table 9: Estimated Dose of Regimen.
Doserine is effective only in moderate to marked AD cases. Doserine 1,2-P 2.5 mg once a day are recommended for most patients with mild to moderate AD [See Warnings and Precautions (5.0), Clinical Pharmacology (12.1)].
Osmotic Diarrhea
The use of osmotically active oral contraceptives is not recommended for use in patients with the following conditions where there is an increased risk of the use osmotically active oral contraceptives in the postpartum period:
severe dehydration;
renal failure;
severe electrolyte disturbances.
Antiepileptic Therapy with Topiramate
If the drug therapy is continued for the first two days following delivery, the woman's milk supply is reduced or she not able to breast-feed, osmotic diarrhea may result. If is severe and persistent, it may lead to the use of a colostomy bag to manage the diarrhea [see Contraindications (4.7)].
Clinically Important Drug Interactions
Antiepileptic drugs (AEDs) which lower the plasma level of GABA, particularly topiramate, may cause a reversible inhibition of l -glutamate dehydrogenase (LGDH), possibly by acting
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In a study with 10 subjects randomized to receive either 500 mg and 0.1 of topiramate once each day or placebo, it was shown that the topiramate -based group had a tendency to have
Levonorgestrel 0.75mg tablet price lower LGDH activity; however, this difference was not statistically significant. [see Warnings and Precautions (5.0)].
Other Potential Interactions
The following medications should be used with caution in a patient diabetes mellitus and an estrogen/progestin-receptor mutation.
Drugs containing choline esters of a similar structure or with other GABA-quinone moieties such as phenylbutazone or pemoline should be avoided in women with diabetes mellitus receiving osmotically active oral contraceptives because of the potential for
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The following medications can increase plasma level of topiramate and can thus lower the plasma level of GABA. These include, but are not limited to, topiramate, phenylbutazone, and other
Lumigan price canada substances such as the antihistaminic drugs dapsone, cinazac, and dipyridamole. The following combinations of medications are not recommended because of decreased plasma levels GABA when used in conjunction with topiramate. However, these combinations can be used with caution due to the potential for topiramate decrease plasma levels of GABA. For all these combinations, the patient's plasma concentrations of GABA and/or topiramate will likely need to be re-challenged at one week after treatment in order to ensure that no excess GABA is formed.
Antacids
Phenacizine (PhenoDerm, Bose, Dulcolax, Novex)
Cefadroxil (Cefadrox, Colopro)
Nizoral (Pristiq, Prasteride)
Phenobarbital (Nembutal)
Mirtazapine
Prochlorperazine (Desoxyn)
Rifampin (Rifadin, Rifampin-CYP)
Trifluoperazine (Ditropan, Levulinate)
Nefazodone
Theophylline
Phenytoin
Other Phenytoin (Anafranil, Anafranil Citrate)
Theophylline-containing products such as Advil, Aleve, Celebrex, Dramamine, Dramamine/Dulcolax (Vivitrol), Flutidine (Zovirax), Lariam (Fasotec), Meridia, Omeprazole, Panadol, Rifampin, Silodosin, Trazodone, Trifluoperazine, and others
Other Phenytoin (Adacel), Anafranil-containing products such as Lariam (Fasotec), Levlen (Lomotil), Omeprazole, Panadol, and others; Theophylline-containing products such as Zovirax and Trifluoperazine; phenytoin containing products.
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