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Is salofalk a corticosteroid, has shown some promise at treating multiple sclerosis (MS) in people who are predisposed to the disease. A preliminary clinical trial that tested corticosteroids against oral immunotherapy with a specific antibody against the MS protein deposits called T-cells showed improvement in the patients with most severe form of the disease, known as relapsing-remitting MS. However, there is no cure for MS. So the study has not been published in any peer-reviewed journal. And the study has a huge "cut off" date: it was started back in the 1970s during Richard Nixon's second term, before there was the internet to disseminate scientific information. This was during the era before it became fashionable to get up at five in the morning and look through scientific literature. But a group at Duke University Medical Center, where a group of doctors conducted the study, is now looking into whether a similar type of immune-treating immunotherapy could provide a cure. The trial, which is still in the planning stages, is aimed at helping people with a severe form of MS known as secondary progressive (SPMS). If results are similar to those seen in the latest trial, it could revolutionise how the disease is treated. A similar treatment using an immune-boosting peptide, called TNFα blocker tacrolimus, was reported last year as being able salofalk 500 mg deutschland to stop progression of an earlier version MS. If that was shown to be effective for people with milder forms of MS, the potential for a breakthrough would be immense. But a study published last summer found the approach was not very effective for people with SPMS who had not progressed. What is MS? This condition is caused by an immune system attack on the myelin sheath covering nerve cells in the brain and body. The attack is known to stop the muscles working properly, making it hard to speak or walk. As the immune system attacks sheath, some parts of the brain and nerve tissues become swollen. The symptoms can also progress and lead to damage the central nervous system (CNS). Around half a million people in the UK are affected by MS, which affects up to 15 millions around the world. How is MS treated? One of the main causes relapse in MS is the immune system overreacting to lesions – called relapses. Overreacting is the reason why an "autoimmune" form of the disease causes more muscle atrophy in people with MS compared to healthy individuals. This is known as multiple sclerosis or relapsing remitting MS (RRMS). It can lead to a loss of mobility, paralysis, blurred vision and muscle weakness. The treatments that have helped many people with RRMS since they were first diagnosed are anti-inflammatory drugs and steroid medications. Taclobutramine is an immune-boosting molecule called immunomodulator that has a wide range of beneficial health benefits. The Duke group is looking at whether that treatment might also help treat MS. They are testing Tklobutramine in people at high risk of developing MS and in patients for the first time. "Taclobutramine blocks the activity of immune system's response to the lesions. It works by blocking an anti-inflammatory molecule called interleukin-12," says Professor Daniela Rusconi, who is leading the trial. "And in people with SPMS, we have a large number being tested." The trial will involve 60 people at high risk of developing MS in London's South Bank. This means they have already had one or more medical surgical condition that increased their risk of developing MS. All trials have to go through a stringent planning and oversight process involving multiple stakeholders including government, the NHS, research firms and pharmaceutical companies.

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